Fig 1: Adult oligodendrogenesis from hippocampal OPCs in APP/PS1 mice. (A) Confocal images of EGFP and ASPA in CA3 of the hippocampus in 12-month-old Pdgfra-CreER; R26-EGFP; ± APP/PS1 (P70 + 300) mice. (B,C) Densities of EGFP+ cells (B) and EGFP+ ASPA+ OLs (C). (D) Percentage of ASPA+ OLs among EGFP+ cells. (E) Confocal images of NG2+ OPCs and Aβ deposits in CA4 of 12-month-old control and APP/PS1 mice. (F) Quantification of OPCs. (G) Confocal images of BCAS1+ newly formed myelinating OLs and Aβ deposits in CA4. (H) Quantification of BCAS1+ cells. Scale bars: 50 μm (A,E,G). No significant change was observed between control and APP/PS1 mice. Two-Way ANOVA and Sidak’s multiple comparisons test. n = 3 or 4 mice for each group.